abstract：:Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligode...

journal_title：Experimental neurology

authors： Zhang W,Wang H,Zhang H,Leak RK,Shi Y,Hu X,Gao Y,Chen J

更新日期：2015-10-01 00:00:00

abstract：:An inherited deficiency of β-galactosylceramidase (GALC) causes the lysosomal storage disease globoid cell leukodystrophy (GLD). The disease is characterized by the accumulation of the cytotoxic metabolite psychosine (galactosylsphingosine), causing rapid degeneration of myelinating cells. Most patients suffer from th...

journal_title：Experimental neurology

authors： Matthes F,Andersson C,Stein A,Eistrup C,Fogh J,Gieselmann V,Wenger DA,Matzner U

更新日期：2015-09-01 00:00:00

abstract：:Diffuse axonal injury is thought to be the basis of the functional impairments stemming from mild traumatic brain injury. To examine how axons are damaged by traumatic events, such as motor vehicle accidents, falls, sports activities, or explosive blasts, we have taken advantage of the spinal cord with its extensive w...

journal_title：Experimental neurology

authors： del Mar N,von Buttlar X,Yu AS,Guley NH,Reiner A,Honig MG

更新日期：2015-09-01 00:00:00

abstract：:Traumatic CNS injury triggers a systemic inflammatory response syndrome (SIRS), in which circulating inflammatory cells invade body organs causing local inflammation and tissue damage. We have shown that the SIRS caused by spinal cord injury is greatly reduced by acute intravenous treatment with an antibody against th...

journal_title：Experimental neurology

authors： Weaver LC,Bao F,Dekaban GA,Hryciw T,Shultz SR,Cain DP,Brown A

更新日期：2015-09-01 00:00:00

abstract：:Paclitaxel is an effective chemotherapeutic agent that, despite its common use, often causes peripheral sensory neuropathy. In neurons, paclitaxel binds to and stabilizes microtubules, and through unknown mechanisms, bundles microtubules and disrupts their organization. Because microtubules serve as tracks on which a ...

journal_title：Experimental neurology

authors： Bober BG,Gutierrez E,Plaxe S,Groisman A,Shah SB

更新日期：2015-09-01 00:00:00

abstract：:Temporomandibular disorders (TMDs) are orofacial pains within the trigeminal distribution, which involve the masticatory musculature, the temporomandibular joint or both. Their pathophysiology remains unclear, as inflammatory mediators are thought to be involved, and clinically TMD presents pain and sometimes limitati...

journal_title：Experimental neurology

authors： Romero-Reyes M,Pardi V,Akerman S

更新日期：2015-09-01 00:00:00

abstract：:Diabetes mellitus is a common metabolic disease in human beings with characteristic symptoms of hyperglycemia, chronic inflammation and insulin resistance. One of the most common complications of early-onset diabetes mellitus is peripheral diabetic neuropathy, which is manifested either by loss of nociception or by al...

journal_title：Experimental neurology

authors： Heng LJ,Qi R,Yang RH,Xu GZ

更新日期：2015-09-01 00:00:00

abstract：:Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR) is characterized by a chronic, fatigable weakness of voluntary muscles. The production of autoantibodies involves the dysregulation of T cells which provide the environment for the development of autoreactive B cells. The symptoms are cau...

journal_title：Experimental neurology

authors： Losen M,Martinez-Martinez P,Molenaar PC,Lazaridis K,Tzartos S,Brenner T,Duan RS,Luo J,Lindstrom J,Kusner L

更新日期：2015-08-01 00:00:00

abstract：:The increasing demand on diagnostic assays that are sensitive and specific for pathogenic antibodies, and the interest in identifying new antigens, prompted the development of cell-based assays for the detection of autoantibodies in myasthenia gravis and other autoimmune disorders. Cell-based assays were initially use...

journal_title：Experimental neurology

authors： Rodriguez Cruz PM,Huda S,López-Ruiz P,Vincent A

更新日期：2015-08-01 00:00:00

abstract：:Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the sma...

journal_title：Experimental neurology

authors： Felling RJ,Song H

更新日期：2015-06-01 00:00:00

abstract：:Many neurological and psychiatric disorders exhibit gender disparities, and sex differences in the brain likely explain some of these effects. Recent work in rodents points to a role for epigenetics in the development or maintenance of neural sex differences, although genome-wide studies have so far been lacking. Here...

journal_title：Experimental neurology

authors： Shen EY,Ahern TH,Cheung I,Straubhaar J,Dincer A,Houston I,de Vries GJ,Akbarian S,Forger NG

更新日期：2015-06-01 00:00:00

abstract：:Exposure to early life stress (ELS), such as childhood abuse and neglect is a well established major risk factor for developing psychiatric and behavioral disorders later in life. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult pathological states where the type and timing ...

journal_title：Experimental neurology

authors： Provençal N,Binder EB

更新日期：2015-06-01 00:00:00

abstract：:We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the in...

journal_title：Experimental neurology

authors： Edri-Brami M,Sharoni H,Hayoun D,Skutelsky L,Nemirovsky A,Porgador A,Lichtenstein RG

更新日期：2015-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease in which the majority of upper and lower motor neurons are degenerated. Despite intensive efforts to identify drug targets and develop neuroprotective strategies, effective therapeutics for ALS remains unavailable. The identificatio...

journal_title：Experimental neurology

authors： Ng SK,Higashimori H,Tolman M,Yang Y

更新日期：2015-05-01 00:00:00

abstract：:Mirror-image pain is a phenomenon in which unprovoked pain is detected on the uninjured contralateral side after unilateral nerve injury. Although it has been implicated that enhanced production of nerve growth factor (NGF) in the contralateral dorsal root ganglion is important in the development of mirror-image pain,...

journal_title：Experimental neurology

authors： Kambiz S,Brakkee EM,Duraku LS,Hovius SE,Ruigrok TJ,Walbeehm ET

更新日期：2015-05-01 00:00:00

abstract：:The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

journal_title：Experimental neurology

authors： Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

更新日期：2015-05-01 00:00:00

abstract：:l-DOPA therapy in Parkinson's disease often results in side effects such as l-DOPA-induced dyskinesia (LID). Our previous studies demonstrated that defective desensitization of dopamine receptors caused by decreased expression of G protein-coupled receptor kinases (GRKs) plays a role. Overexpression of GRK6, the isofo...

journal_title：Experimental neurology

authors： Ahmed MR,Bychkov E,Kook S,Zurkovsky L,Dalby KN,Gurevich EV

更新日期：2015-04-01 00:00:00

abstract：:The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local antagonism of GABA-A receptors within the striatum produces tic-like p...

journal_title：Experimental neurology

authors： Pogorelov V,Xu M,Smith HR,Buchanan GF,Pittenger C

更新日期：2015-03-01 00:00:00

abstract：:Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gam...

journal_title：Experimental neurology

authors： Bian H,Hu Q,Liang X,Chen D,Li B,Tang J,Zhang JH

更新日期：2015-03-01 00:00:00

abstract：:We have previously shown that the expression of voltage-operated Ca(++) channels (VOCCs) is highly regulated in the oligodendroglial lineage and is essential for proper oligodendrocyte progenitor cell (OPC) migration. Here we assessed the role of VOCCs, in particular the L-type, in oligodendrocyte maturation. We used ...

journal_title：Experimental neurology

authors： Cheli VT,Santiago González DA,Spreuer V,Paez PM

更新日期：2015-03-01 00:00:00

abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

journal_title：Experimental neurology

authors： Gess B,Röhr D,Lange E,Halfter H,Young P

更新日期：2015-02-01 00:00:00

abstract：:Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression...

journal_title：Experimental neurology

authors： Gordon T,You S,Cassar SL,Tetzlaff W

更新日期：2015-02-01 00:00:00

abstract：:Injection of lysosomal enzyme into cisternal or ventricular cerebrospinal fluid (CSF) has been carried out in 11 lysosomal storage disorder models, with each study demonstrating reductions in primary substrate and secondary neuropathological changes, and several reports of improved neurological function. Whilst acute ...

journal_title：Experimental neurology

authors： Marshall NR,Hassiotis S,King B,Rozaklis T,Trim PJ,Duplock SK,Winner LK,Beard H,Snel MF,Jolly RD,Hopwood JJ,Hemsley KM

更新日期：2015-01-01 00:00:00

abstract：:Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplyi...

journal_title：Experimental neurology

authors： Morrison BM,Tsingalia A,Vidensky S,Lee Y,Jin L,Farah MH,Lengacher S,Magistretti PJ,Pellerin L,Rothstein JD

更新日期：2015-01-01 00:00:00

abstract：:Injury of a peripheral nerve not only leads to target denervation, but also induces massive stripping of spinal synapses on axotomized motoneurons, with disruption of spinal circuits. Even when regeneration is successful, unspecific reinnervation and the limited reconnection of the spinal circuits impair functional re...

journal_title：Experimental neurology

authors： Arbat-Plana A,Torres-Espín A,Navarro X,Udina E

更新日期：2015-01-01 00:00:00

abstract：:Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might be based on overactivity of multidrug ...

journal_title：Experimental neurology

authors： Klein S,Bankstahl JP,Löscher W,Bankstahl M

更新日期：2015-01-01 00:00:00

abstract：:Multiple sclerosis (MS), the most frequent inflammatory disease of the central nervous system (CNS), affects about two and a half million individuals worldwide and causes major burdens to the patients, which develop the disease usually at the age of 20 to 40. MS is likely referable to a breakdown of immune cell tolera...

journal_title：Experimental neurology

authors： Schattling B,Eggert B,Friese MA

更新日期：2014-12-01 00:00:00

abstract：:One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...

journal_title：Experimental neurology

authors： Bennion Callister J,Pickering-Brown SM

更新日期：2014-12-01 00:00:00

abstract：:Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified as a component withi...

journal_title：Experimental neurology

authors： McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O

更新日期：2014-11-01 00:00:00

abstract：:Axonal injury close to cell bodies of motoneurons induces the death of the vast majority of affected cells. Neurotrophic factors, such as brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF), delivered close to the damaged motor pool in a non-regulated manner induce good survival ...

journal_title：Experimental neurology

authors： Pajenda G,Hercher D,Márton G,Pajer K,Feichtinger GA,Maléth J,Redl H,Nógrádi A

更新日期：2014-11-01 00:00:00

abstract：:We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month...

journal_title：Experimental neurology

authors： Morelli E,Ghiglieri V,Pendolino V,Bagetta V,Pignataro A,Fejtova A,Costa C,Ammassari-Teule M,Gundelfinger ED,Picconi B,Calabresi P

更新日期：2014-11-01 00:00:00

abstract：:Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim of the present study was to define the importance of E4 in the attenuation of neonatal hypoxic-ischemic encephalop...

journal_title：Experimental neurology

authors： Tskitishvili E,Nisolle M,Munaut C,Pequeux C,Gerard C,Noel A,Foidart JM

更新日期：2014-11-01 00:00:00

abstract：:Anisotropy indices derived from diffusion tensor imaging (DTI) are being increasingly used as biomarkers of central WM structural maturation, myelination and even functional development. Our hypothesis was that the rate of functional changes in central WM tracts directly reflects rate of changes in structural developm...

journal_title：Experimental neurology

authors： Drobyshevsky A,Jiang R,Derrick M,Luo K,Tan S

更新日期：2014-11-01 00:00:00

abstract：:Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...

journal_title：Experimental neurology

authors： Sato M,Sagawa Y,Hirai N,Sato S,Okuro M,Kumar S,Kanbayashi T,Shimizu T,Sakai N,Nishino S

更新日期：2014-11-01 00:00:00

abstract：:Decreased brain insulin signaling has been found recently in Alzheimer's disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. However, the underlying mechanisms are unknown. Here, we treated ...

journal_title：Experimental neurology

authors： Chen Y,Zhao Y,Dai CL,Liang Z,Run X,Iqbal K,Liu F,Gong CX

更新日期：2014-11-01 00:00:00

abstract：:The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...

journal_title：Experimental neurology

authors： Krishnan V

更新日期：2014-11-01 00:00:00

abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...

journal_title：Experimental neurology

authors： Sabelström H,Stenudd M,Frisén J

更新日期：2014-10-01 00:00:00

abstract：:Neural stem cell (NSC) transplantation provides a new approach for the repair of damage to the central nervous system (CNS), including that resulting from cerebral infarction and spinal cord injury (SCI). In the past, there were no reputable means of converting non-neural somatic cells into neural cells. This status w...

journal_title：Experimental neurology

authors： Matsui T,Akamatsu W,Nakamura M,Okano H

更新日期：2014-10-01 00:00:00

abstract：:Epidemiological data demonstrate that while women report lower rates of drug use than men, the number of current drug users and abusers who are women continues to increase. In addition women progress through the phases of addiction differently than men; women transition from casual drug use to addiction faster, are mo...

journal_title：Experimental neurology

authors： Bobzean SA,DeNobrega AK,Perrotti LI

更新日期：2014-09-01 00:00:00

abstract：:Cerebral ischemia caused by loss of blood supply to the brain during cardiac arrest or stroke are major causes of death and disability. Biological sex is an important factor in predicting vulnerability of the brain to an ischemic insult, with males being at higher risk for cardio-cerebrovascular events than females of...

journal_title：Experimental neurology

authors： Quillinan N,Deng G,Grewal H,Herson PS

更新日期：2014-09-01 00:00:00